Cognitive correlates of Antisaccade Task performance in bipolar disorder

Abstract

Background: The Antisaccade Task is often used to measure inhibitory control. While pooled effects in meta-analyses demonstrate antisaccade impairments in bipolar disorder (BD), individual studies show considerable variability in effect sizes and case-control significance, particularly in euthymic samples. This variability may reflect cognitive heterogeneity across BD samples. In this exploratory study we investigated whether antisaccade performance correlated with other cognitive domains in BD, and whether impairments were confined to specific cognitive subgroups. Method: 152 individuals (44 BD outpatients and 108 healthy controls [HC]) completed the Antisaccade Task. Participants also comp..